Shopping on line can be easy, simple and save you lots of money. It can also take a lot of your time, frustrate you, and result in unwanted purchases. Now the same can be said for regular high street shopping, but with the vast opportunity presented by the Internet it will pay you to spend a few minutes reading this and understanding how to better optimize your Point Mutation shopping experience:

1. Compare - without doubt the biggest advantage that the Point Mutation offers shoppers today is the ability to compare thousands of Point Mutation at a time. This is a great thing, but not necessarily all the time! Too much can be daunting at times so take advantage of the great comparison sites and where possible let them do the hard work for you.

2. Research - if it has been said it will be on the internet. Ignorance is no longer a justifiable reason for buying the wrong thing. Take the time to research in detail everything that you could possible want to know about

3. Testimonials - don't know anybody that has bought a Point Mutation? Wrong! If the Point Mutation is good the internet will let you know. Use the Internet as a friend and get testimonials before you buy.

4. Questions - Got a question about Point Mutation then search the Forums, FAQ's, Blogs etc. Don't be afraid to ask .....

5. Reputation - Never heard of the company selling Point Mutation? Don't worry, no reason why you should know every company in the world, but you know someone that does! Use the internet to find out what people are saying about Point Mutation and build up a picture of their reputation for sales, returns, customer service, delivery etc.

6. Returns - still worried that even after all of the above your Point Mutation wont be what you want? Check out the returns policy. There is so much competition now that someone, somewhere is bound to offer the terms that you are comfortable with.

7. Feedback - happy with your Point Mutation then let people know, after all you are depending on others people input in your buying decision, so why not give a little back.

8. Security - check for the yellow padlock on the Point Mutation site before you buy, and the s after http:/ /i.e. https:// = a secure site

9. Contact - got a question about Point Mutation, or want to leave a comment then check out the sites contact page. Reputable companies have them and respond.

10. Payment - ready to pay for your Point Mutation, then use your credit card or PayPal! Be aware of companies that don't accept them, there may be genuine reasons but given the huge amount of choice you have when buying online there is no reason at all not to buy via credit card or PayPal.

A point mutation, or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide. One can categorize point mutations as follows:

• transitions: replacement of a purine base with another purine or replacement of a pyrimidine with another pyrimidine
• transversions: replacement of a purine with a pyrimidine or vice versa.

Transition mutations are about an order of magnitude more common than transversions. Point mutations can also be categorized functionally:

• nonsense mutations: code for a stop, which can truncate the protein
• missense mutations: code for a different amino acid
• silent mutations: code for the same amino acid.

For example, sickle-cell disease is caused by a single point mutation (a missense mutation) in the beta-hemoglobin gene that converts a GAG codon into GTG, which encodes the amino acid valine rather than glutamic acid.

Point mutations that occur in non-coding sequences are most often without consequences, although there are exceptions. If the mutated base pair is in the promoter sequence of a gene, then the expression of the gene may change. Also, if the mutation occurs in the splicing seat of an intron, then this may interfere with correct splicing of the transcribed pre-mRNA.

Sometimes the term point mutation is also used to describe insertion (genetics) or deletions of a single base pair (which has more of an adverse effect on the synthesized protein due to the nucleotides' still being read in triplets, but in different frames: a mutation called a frameshift mutation).

Causes Point mutations may arise from spontaneous mutations that occur during DNA replication. The rate of mutation may be increased by mutagens. Mutagens can be physical, such as radiation from ultraviolet light, X-rays or extreme heat, or chemical (molecules that misplace base pairs or disrupt the helical shape of DNA). Mutagens associated with cancers are often studied to learn about cancer and its prevention.

External links

A point mutation, or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide. One can categorize point mutations as follows:

• transitions: replacement of a purine base with another purine or replacement of a pyrimidine with another pyrimidine
• transversions: replacement of a purine with a pyrimidine or vice versa.

Transition mutations are about an order of magnitude more common than transversions. Point mutations can also be categorized functionally:

• nonsense mutations: code for a stop, which can truncate the protein
• missense mutations: code for a different amino acid
• silent mutations: code for the same amino acid.

For example, sickle-cell disease is caused by a single point mutation (a missense mutation) in the beta-hemoglobin gene that converts a GAG codon into GTG, which encodes the amino acid valine rather than glutamic acid.

Point mutations that occur in non-coding sequences are most often without consequences, although there are exceptions. If the mutated base pair is in the promoter sequence of a gene, then the expression of the gene may change. Also, if the mutation occurs in the splicing seat of an intron, then this may interfere with correct splicing of the transcribed pre-mRNA.

Sometimes the term point mutation is also used to describe insertion (genetics) or deletions of a single base pair (which has more of an adverse effect on the synthesized protein due to the nucleotides' still being read in triplets, but in different frames: a mutation called a frameshift mutation).

Causes Point mutations may arise from spontaneous mutations that occur during DNA replication. The rate of mutation may be increased by mutagens. Mutagens can be physical, such as radiation from ultraviolet light, X-rays or extreme heat, or chemical (molecules that misplace base pairs or disrupt the helical shape of DNA). Mutagens associated with cancers are often studied to learn about cancer and its prevention.

External links

Point mutation - Wikipedia, the free encyclopedia
A point mutation, or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide.

Mutation - Wikipedia, the free encyclopedia
A point mutation, or substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide. Often the term point mutation also includes ...

Definition: point mutation from Online Medical Dictionary
The Online Medical Dictionary is a searchable dictionary of definitions from medicine, science and technology.

Introduction to Human Genetics: Mutation
Mutation. Mutation is the alteration of DNA sequence, whether it be in a small way by the alteration of a single base pair, or whether it be a gross event such as the gain or loss ...

Glasgow ePrints Service - A point mutation leading to hepatitis C ...
A challenge in hepatitis C virus vaccine development is defining conserved protective epitopes. A cluster of these epitopes comprises an immunodominant domain on the E2 ...

Point Mutation
Encyclopedia information on Point Mutation ... Point Mutation. A point mutation is a particular type of mutation that is responsible for the replacement of a single base nucleotide ...

MLPA-based point mutation analysis of the FBN1 gene in Marfan syndrome
MLPA-based point mutation analysis of the FBN1 gene in Marfan syndrome David J. Bunyan 1,2, T Brown 3, R Wycherley 2, JC Score 2, JF Harvey 1,2, NCP Cross 1,2. 1 National Genetics ...

e-Prints Soton - MLPA-based point mutation analysis of the FBN1 gene ...
The Multiplex Ligation-depandant Probe Amplification assay (MLPA) detects whole-exon deletions or duplications (Schouten et al 2002). These mutations are present at a significant ...

e-Prints Soton - Simultaneous MLPA-based multiplex point mutation and ...
The Multiplex Ligation-dependent Probe Amplification assay (MLPA) is the method of choice for the initial mutation screen in the analysis of a large number of genes where partial ...

POINTMUTATION.COM
Point Mutation Web :) :P :D